Analysis of Resting State Functional Connectivity in a Cognitive Training Intervention Study

Aug 27, 2016 by

Abstract: As part of a larger randomized controlled study by Hill, Zewelanji, and Faison (2015), 30

of the 225 participating high school students were randomly assigned to one of three conditions:

ThinkRx, BrainSkills, or study hall (control). In addition to pre and post cognitive testing these

students underwent pre and post MRI imaging. Functional MRI was used to assess changes in

resting state functional connectivity associated with cognitive training, and correlation of changes in

functional connectivity to cognitive testing findings. Analysis of cognitive testing scores found that

the cognitive training groups scored significantly higher than controls on multiple tasks, with the most

significant gain occurring in auditory processing: auditory analysis segmenting (F=16.3, p=0.000)

and auditory analysis drop (F=13.6, p=0.001). Analysis of resting state connectivity with the auditory

cortex (superior temporal gyrus and right anterior temporal gyrus) revealed significant changes in

the resting state connectivity with multiple cortical regions involved in cognitive processing (Figure

1). In addition, an increase in global network efficiency (network T=2.44, p-unc 0.02; PaCiG l : T=4.56,

p-FDR=.01; MedFC: T=4.14, p-FDR=0.02; pITG l: T=-3.05, p-FDR=0.23; aSTG r: T=2.86, p-FDR=0.27)

was found to occur following cognitive training (Figure 2). Further, analysis revealed that network

changes correlated to auditory processing gains.


Reference: Ledbetter, C., Faison, M., Hill, O., & Patterson, J. (2016). Analysis of Resting State Functional Connectivity in a Cognitive Training Intervention Study. Poster presented at Center for Brain Health Annual Symposium: Reprogramming the Brain to Health: Computational Psychiatry and Neurology, University of Texas at Dallas, April 14, 2016.

The full results can be found in LearningRx’s 48-page 2016 edition of “Client Outcomes and Research Results.”